"Que Sera Sera" is a song that was written and performed by Doris Day. Part of the song is featured panels 1289 to 1306, as the machine jabs Prudith with a syringe, while lasers ripped apart her body leaving only the brain and nerves.
"Que será será," in Spanish, translates to "what will be will be." This could be symbolic of how Followers give all faith and thought to TITAN, and whatever the machine does "will be." It relies on innate trust in TITAN, and believing that He knows best, which is how He controls much of his voluntary followers.